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Deep-Brain Stimulation for Parkinson’s Disease 

Deep-Brain Stimulation for Parkinson’s Disease
Chapter:
Deep-Brain Stimulation for Parkinson’s Disease
Author(s):

Sarah E. Buckingham

DOI:
10.1093/med/9780199377527.003.0010
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date: 14 July 2020

This chapter provides a summary of a landmark study in movement disorders. Is neurostimulation superior to best medical management in patients with advanced Parkinson’s disease? Starting with that question, it describes the basics of the study, including funding, study location, who was studied, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. Subthalamic neurostimulation resulted in a signficant and clinically meaningful improvement in the quality of life of patients under 75 years of age who had advanced Parkinson’s disease with parkinsonian motor symptoms or dyskinesias. The chapter briefly reviews other relevant studies and information, and concludes with a relevant clinical case.

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