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Cholinesterase Inhibitors for Alzheimer’s Disease 

Cholinesterase Inhibitors for Alzheimer’s Disease
Chapter:
Cholinesterase Inhibitors for Alzheimer’s Disease
Author(s):

Ashish L. Ranpura

DOI:
10.1093/med/9780199377527.003.0001
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date: 15 September 2019

This chapter provides a summary of a landmark study in behavioral neurology. Does donepezil improve cognitive and global functional outcomes in patients with Alzheimer’s disease? Starting with that question, it describes the basics of the study, including funding, study location, who was studied, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. The study demonstrated that 5 and 10 mg daily donepezil effectively slowed the cognitive decline associated with AD for up to 6 months in a dose-dependent fashion; however, the absolute benefits were modest. The chapter briefly reviews other relevant studies and information, and concludes with a relevant clinical case.

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