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Hypothermia and Fever Control in Neurocritical Care 

Hypothermia and Fever Control in Neurocritical Care
Hypothermia and Fever Control in Neurocritical Care

Kees H. Polderman

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date: 06 April 2020

The brain is responsible for thermoregulatory control, and brain injury can result in disruptions to this system. Temperature management is a crucial component of neurocritical care, as temperature can modify cellular injury. Hyperthermia has clearly and consistently shown detrimental effects after brain injury, prompting the increasing focus on targeted temperature control. Hypothermia has numerous mechanisms that have led to it being considered as a possible neuroprotectant for reducing secondary brain injury from multiple causes. However, while animal studies have demonstrated clear beneficial effects, robust clinical trials have not reported the same level of benefit in a consistent fashion. This chapter reviews the physiology, mechanisms of action, and current evidence and provides practical suggestions regarding temperature management in the neurocritical care patient.

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