Show Summary Details
Page of

Inflammation and Demyelination 

Inflammation and Demyelination
Chapter:
Inflammation and Demyelination
Author(s):

Daniel B. Rubin

, and Henrikas Vaitkevicius

DOI:
10.1093/med/9780199375349.003.0012
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2020. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 30 March 2020

Autoimmune disease affecting the central nervous system is a common cause for admission to the neurointensive care unit. Although well-described clinical syndromes exist, patients more commonly present with progressive neurologic dysfunction and some combination of laboratory and radiographic evidence of central nervous system inflammation. The urgency to intervene to prevent permanent damage to the nervous system often conflicts with diagnostic uncertainty. This chapter outlines some of the basic diagnostic and therapeutic principles of autoimmune diseases of the central nervous system. The chapter characterizes disorders not as a list of individual disease entities but rather as clusters of syndromes based on common underlying mechanisms of immune dysfunction. This approach focuses on early interventions rather than precise diagnosis. As our understanding of the immune system continues to grow, this framework will allow for a more sophisticated approach to the management of patients with these complex, often devastating but frequently reversible, neurologic illnesses.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.