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Peptic Ulcer Disease* 

Peptic Ulcer Disease*
Chapter:
Peptic Ulcer Disease*
Author(s):

Stephanie L. Hansel

DOI:
10.1093/med/9780199373338.003.0049
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date: 19 October 2020

A peptic ulcer is a persistent 5 mm or larger break in the gastrointestinal mucosa of the stomach or duodenum that penetrates through the muscularis mucosa. At endoscopy, an ulcer should be readily apparent with perceivable depth. Smaller and more shallow mucosal breaks represent erosions. Most ulcers are due to infection with Helicobacter pylori or the administration of nonsteroidal anti-inflammatory drugs. The term peptic ulcer disease refers to ulceration that depends in part on the acid and peptic (pepsins) activity of gastric juice. Gastric malignancy is an example of ulceration that may occur in the absence of acid and peptic activity. Most peptic ulcer disease involves the stomach or duodenal bulb. Epidemiology, pathophysiology, diagnosis, testing, and treatment are discussed.

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