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Autoimmune Hepatitisa 

Autoimmune Hepatitisa
Chapter:
Autoimmune Hepatitisa
Author(s):

Kymberly D. Watt

and Albert J. Czaja

DOI:
10.1093/med/9780199373338.003.0037
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date: 04 December 2020

Autoimmune hepatitis is a self-perpetuating inflammation of the liver of unknown cause that is associated with autoantibodies, hypergammaglobulinemia, and interface hepatitis seen on histologic examination. Autoimmune hepatitis afflicts 100,000 to 200,000 persons in the United States annually and accounts for 5.9% of liver transplants performed in the United States. The cause of autoimmune hepatitis is unknown. Multiple agents have been implicated as triggers of the disease, including certain viruses (hepatitis A, hepatitis B, hepatitis C, Epstein-Barr, herpes simplex, and measles viruses) and drugs (diclofenac, isoniazid, ?-methyldopa, minocycline, nitrofurantoin, atorvastatin, and propylthiouracil; recently, infliximab and adalimumab have been implicated). Hepatitis A virus infection and minocycline have been implicated most often worldwide. Most cases have no identifiable trigger.

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