Show Summary Details
Page of

Ascites, Hepatorenal Syndrome, and Encephalopathy 

Ascites, Hepatorenal Syndrome, and Encephalopathy
Chapter:
Ascites, Hepatorenal Syndrome, and Encephalopathy
Author(s):

J. Eileen Hay

DOI:
10.1093/med/9780199373338.003.0033
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2020. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 27 February 2020

The portal hypertension and hepatic synthetic dysfunction of cirrhosis cause three main complications as liver disease progresses: variceal bleeding, ascites, and hepatic encephalopathy. Ascites is the most common major complication of cirrhosis and occurs in about 50% of patients with compensated cirrhosis in 10 years. The development of ascites denotes the transition from compensated to decompensated cirrhosis. Hepatic encephalopathy is a debilitating complication of cirrhosis for which therapies are still very limited and nonspecific. Furthermore, no weight is given for this complication in the MELD system for organ allocation, resulting in considerable morbidity for patients and a burden for families and the health care system. In chronic liver disease, noxious substances, presumed nitrogenous compounds from protein breakdown, are ineffectively detoxified or bypassed (or both) by the diseased liver and affect the brain, causing a neuropsychiatric syndrome called hepatic encephalopathy.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.