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Barrett Esophagus and Esophageal Cancer 

Barrett Esophagus and Esophageal Cancer
Chapter:
Barrett Esophagus and Esophageal Cancer
Author(s):

Prasad G. Iyer

DOI:
10.1093/med/9780199373338.003.0002
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date: 20 February 2020

Barrett esophagus is an acquired condition characterized by the replacement of the squamous epithelium lining the esophagus by partially intestinalized columnar epithelium. It is thought to be a complication of gastroesophageal reflux and may reflect an adaptive response to reflux of gastric contents into the esophagus. It is the strongest known risk factor for esophageal adenocarcinoma. Barrett esophagus is characterized by proximal displacement of the squamocolumnar junction in the esophagus and has been classified into long-segment Barrett esophagus (visible columnar mucosa in the esophagus of 3 cm or more) and short-segmentBarrett esophagus (visible columnar mucosa in the esophagus less than 3 cm in length). Etiology, risk factors, screening and surveillance for esophageal cancer are discussed. Cancer presentation, symptoms, diagnosis, and treatment of the disease are also addressed.

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