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Inflammatory Bowel Disease: Clinical Aspects 

Inflammatory Bowel Disease: Clinical Aspects
Chapter:
Inflammatory Bowel Disease: Clinical Aspects
Author(s):

David H. Bruining

DOI:
10.1093/med/9780199373338.003.0018
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date: 29 February 2020

Inflammatory bowel disease (IBD) remains a vexing clinical challenge. It is a disease process characterized by chronic idiopathic intestinal inflammation. The two main subtypes are ulcerative colitis and Crohn disease. Ulcerative colitis involves the colonic mucosa, extending proximally from the anal verge in an uninterrupted pattern to involve all or part of the colon. Crohn disease is a disorder that typically affects the full thickness of the intestine. Although it has a special predilection for involving the small bowel, the disease can occur anywhere in the gastrointestinal tract from mouth to anus.

Typically, Crohn disease results in patchy inflammation with intervening areas of normal mucosa. Both ulcerative colitis and Crohn disease can be associated with extra-intestinal disease manifestations.

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