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Nonvariceal Gastrointestinal Tract Bleedinga 

Nonvariceal Gastrointestinal Tract Bleedinga
Nonvariceal Gastrointestinal Tract Bleedinga

Jeffrey A. Alexander

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date: 22 October 2020

Upper gastrointestinal tract bleeding (“UGI bleeding”) constitutes 75% to 80% of all cases of acute gastrointestinal tract bleeding. The incidence has decreased, but the mortality rate from acute UGI bleeding, ranging from 3% to 10%, has not changed appreciably in the past 50 years. This lack of change in mortality rate likely is related to the increased age of patients who present with UGI bleeding and the increase in associated comorbid conditions. Peptic ulcers are the most common source of UGI bleeding, accounting for about 40% of cases. Other major causes are gastric erosions, bleeding varices, and Mallory-Weiss tears. The use of aspirin or nonsteroidal anti-inflammatory drugs is prevalent in 45% to 60% of all cases of acute bleeding. Moreover, the risk of UGI bleeding is increased in patients who take as few as one “baby aspirin” per day.

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