Neurobiology of Addictions

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Neurobiology of Addictions

Edited by Alan C. Swann, F. Gerard Moeller, and Marijn Lijffijt

Abstract

This book addresses (1) candidate mechanisms across addictive behaviors, including impulsivity (Chapters 1–5); reward sensitivity (Chapter 2); behavioral sensitization and cross-sensitization to addictive, stressful, or endogenous illness-related stimuli (Chapters 1, 5–8, 13); and genetics (Chapter 11). Addictions frequently combine with other psychiatric disorders; each increases severity of the other (Chapters 1, 7, 13). Genetic or epigenetic mechanisms underlying addictive processes may overlap with those involved in predisposing illnesses (Chapters 5, 11, 13). Addressed are (2) resilience to addictions despite substance use (Chapters 1, 3–5, 7, 13); (3) clinical contexts of addictive behavior, including nicotine (Chapter 3, early onset), opiates (Chapter 4; resilience and impulsivity), alcohol (Chapter 5; stimulant-like effects), stimulants (Chapter 9), marijuana and cannabinoids (Chapter 10; endocannabinoid systems strategic role in motivation and reward), nonpharmacological addictions (Chapter 8; sexual addictions), and interactions between addictions and other recurrent/progressive brain diseases (Chapters 1, 13). Topics include (4) strategies for addiction prevention and treatment, including targets related to impulsivity (Chapters 1, 2, 4, 5), decision-making (Chapter 2), sensitization (Chapters 1, 13), and prevention (Chapters 5, 13); nonpharmacological treatments for impulsivity (Chapters 2, 4), decision-making (Chapter 2), and sensitization prevention (Chapter 13), pharmacogenetics (Chapter 11), and study design and analysis strategies that account for complex neurobehavioral interactions underlying addiction treatment (Chapter 12). Chapter 13 integrates addictive and other psychiatric diseases, especially regarding progression and sensitization, in a clinically oriented manner. Understanding the basic neurobehavioral mechanisms and sources of resilience against them will lead to more effective prevention, diagnosis, and treatment.

Bibliographic Information

Publisher:: Oxford University Press

Print Publication Date:: Apr 2016

Print ISBN-13:: 9780199367894

Published online:: Jun 2016

DOI:: 10.1093/med/9780199367894.001.0001

Authors

Alan C. Swann, editor Professor and Vice-Chair for Research and Co-Director, Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, the University of Texas Health Science Center at Houston

F. Gerard Moeller, editor Professor and Vice-Chair for Translational Research and Director of the Center for Neurobehavioral Research on Addictions, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston

Marijn Lijffijt, editor Research Associate, Menninger Department of Psychiatry and Behavioral Sciences Baylor College of Medicine

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Oxford University Press makes no representation, express or implied, that the drug dosages in this book are correct. Readers must therefore always check the product information and clinical procedures with the most up to date published product information and data sheets provided by the manufacturers and the most recent codes of conduct and safety regulations. The authors and the publishers do not accept responsibility or legal liability for any errors in the text or for the misuse or misapplication of material in this work. Except where otherwise stated, drug dosages and recommendations are for the non-pregnant adult who is not breastfeeding.

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Front Matter
- Preface
- Contributors
1 Beyond Drugs: Addictions in the Context of Recurrent/Progressive Psychiatric Illness Alan C. Swann
2 Behavioral Mechanisms in Addiction Margaret C. Wardle, Jin H. Yoon, Anka A. Vujanovic, Michael F. Weaver, Scott D. Lane, and Joy M. Schmitz
3 The Biology of Nicotine Addiction and Factors That Differentiate Youth Who Smoke From Those Who Do Not Felicia R. Carey and Anna V. Wilkinson
4 Resilience and Opiate Misuse Sameer Hassamal, Divya Ramesh, and F. Gerard Moeller
5 Alcohol-Related Disorders: Adaptations and Progression to Disordered Drinking Therese A. Kosten, Colin N. Haile, Marijn Lijffijt, and Alan C. Swann
6 The Neurobiology of Behavioral Sensitization Jeffery D. Steketee
7 Stress and Addiction Marijn Lijffijt
8 The Neurobiology of Behavioral Addictions: Sexual Addiction Donald L. Hilton Jr., Stefanie Carnes, and Todd L. Love
9 Norepinephrine as a Therapeutic Target for Cocaine Use Disorder Colin N. Haile, Thomas F. Newton, and Thomas R. Kosten
10 Cannabis, Endocannabinoids, and Mechanisms of Addiction Christopher Rodgman and Christopher D. Verrico
11 Cocaine Addiction Therapy Pharmacogenetics David A. Nielsen
12 Increasing the Information Yield From Clinical Trials in Addictions: Bayesian Statistics, Adaptive Designs, and Biomarker Evaluation Charles Green, Robert Suchting, Nuvan Rathnayaka, Margaret C. Wardle, and Joy M. Schmitz
13 Mechanisms of Sensitization to Stress, Affective Episodes, and Abused Substances: Implications for Treatment and Prevention Robert M. Post
End Matter
- Index

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date: 26 February 2021

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Neurobiology of Addictions

Edited by Alan C. Swann, F. Gerard Moeller, and Marijn Lijffijt

Abstract

Bibliographic Information

Authors

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Contents