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Neuropathology of Autism Spectrum Disorder 

Neuropathology of Autism Spectrum Disorder
Chapter:
Neuropathology of Autism Spectrum Disorder
Author(s):

Matthew P. Anderson

DOI:
10.1093/med/9780199349722.003.0013
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date: 24 May 2022

This chapter reviews results from studies of neuropathology of autism spectrum disorder (ASD). As with the known clinical presentation and genetic underpinnings of ASD, results from studies of the postmortem brain have yielded a similar degree of heterogeneity. It is hypothesized that by conducting studies of postmortem brain from genetically defined subtypes of ASD, the heterogeneity of findings can begin to be reduced. This chapter highlights results from postmortem study of particular areas of the brain, such as the cerebral cortex and cerebellum. Changes in neurotransmitter systems, a description of neurodegenerative-type processes, and abnormalities due to comorbid epilepsy are also discussed. The chapter concludes with a discussion of the role of the innate immune system in postmortem brain of those with ASD.

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