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Non-Opioid Medications 

Non-Opioid Medications
Non-Opioid Medications

Adam Canter

, Vijay Babu

, and Karina Gritsenko

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date: 15 July 2020

This chapter examines the role of non-opioid medications in acute on chronic pain management for the hospitalized patient. Such medications include nonsteroidal anti-inflammatory drugs, antidepressants, local anesthetics, membrane stabilizers, and ketamine. Non-opioid medications may have a significant opioid-sparing effect in the hospital setting. Distinguishing between neuropathic and somatic pain, and weighing the risks and benefits with regard to the mechanism of action as well as the side-effect profile of each non-opioid agent used are essential for safe and effective pain control. A delicate balance needs to be maintained for each individual patient, based on history, physical exam, comorbidities, medication profile, and specific acute on chronic pain needs.

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