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Hereditary Cancer Syndromes 

Hereditary Cancer Syndromes
Chapter:
Hereditary Cancer Syndromes
Author(s):

David Malkin

DOI:
10.1093/med/9780199335114.003.0007
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date: 17 April 2021

Many genes play important roles in the development of sporadic cancers and their identification and functional characterization have led to better understanding of cancer biology and potential new therapeutic targets. It is likely that as more cancer predisposition syndromes are characterized and more “cancer genes” are identified, causal associations between the two will continue to develop. Hereditary cancers touch more areas of a patient’s life and family than a childhood cancer diagnosis usually does. Although most parents of children with cancer can be reassured that it is highly unlikely that their other children will be at increased risk for cancer, this is not the case when the cancer is part of a hereditary syndrome. Thus, genetic counseling and attention to psychosocial concerns of parents and children with hereditary cancers is paramount.

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