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Botanical-Drug Interactions in Oncology—What Is Known? 

Botanical-Drug Interactions in Oncology—What Is Known?
Chapter:
Botanical-Drug Interactions in Oncology—What Is Known?
Author(s):

Alex Sparreboom

and Sharyn D. Baker

DOI:
10.1093/med/9780199329724.003.0009
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date: 18 October 2019

Chapter 9 discusses botanical-drug interactions in oncology, including the popularity of CAM use in cancer patients, how many types of CAM, in particular herbs, have the potential to interact with prescription drugs, altering their pharmacokinetic characteristics and potentially leading to clinically significant interactions, that a number of herbal preparations are known to either inhibit or induce the function of drug-metabolizing enzymes or drug transporters that are of relevance to the pharmacokinetic profile of anticancer drugs, that few clinical studies have been performed that specifically investigated the interaction potential of herbs with anticancer agents and those that have, have typically evaluated the anticancer agents docetaxel, imatinib, or irinotecan as model drugs, and that the intrinsic likelihood of significant pharmacokinetic interactions between most herbs and anticancer drugs is low; however, interactions between St. John's Wort and anticancer agents are likely to have clinical and toxicological implications.

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