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Psychopharmacology in the General Medical Setting 

Psychopharmacology in the General Medical Setting
Psychopharmacology in the General Medical Setting

Robert H. Howland

and Kurt D. Ackerman

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date: 22 September 2020

The principles and practice of clinical psychopharmacology in the medical setting are highly complex. Knowledge about the side-effect profile and pharmacology of various psychotropic drugs is necessary, but not sufficient, for appropriate clinical management. Understanding the effect of psychotropic drugs on different end-organ systems and how end-organ dysfunction will influence pharmacokinetic and pharmacodynamic processes is essential. This chapter reviews general pharmacokinetic and pharmacodynamic processes in relevant psychotropic drug use in medical patients, including drug-drug interactions and routes of drug administration. Special considerations with psychopharmacology in the medical setting are also reviewed, including liver injury, pancreatitis and hyperammonemia, hepatic insufficiency, gastric bypass, renal insufficiency, cardiovascular toxicity, hematologic effects, and falls risks.

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