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Drug Treatment in Women 

Drug Treatment in Women
Chapter:
Drug Treatment in Women
Author(s):

Katherine T. Murray

DOI:
10.1093/med/9780199321971.003.0007
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date: 21 October 2019

In the quest for a personalized approach to modern drug therapy, there is increasing evidence that sex matters. In cardiovascular therapeutics, sex-based considerations are particularly important with the use of antiarrhythmic drugs. In general, women have a greater incidence of adverse outcomes, especially drug-mediated proarrhythmia. Despite numerous studies, the mechanisms responsible for these sex-related differences are not fully understood. For optimal patient safety, practitioners must be aware of sex-based differences in outcomes related to antiarrhythmic drug therapy. This chapter reviews the evidence for the disparate responses between men and women to electrophysiologically active agents and highlights potential drug interactions of unique clinical significance for women.

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