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Sex-Specific Electrophysiologic Properties 

Sex-Specific Electrophysiologic Properties
Sex-Specific Electrophysiologic Properties

Christine Tanaka-Esposito

and Mina K. Chung

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date: 06 May 2021

Clinical and experimental observations suggest that myocardial tissue has sex-specific electrophysiologic properties. These differences (resting heart rate, corrected QT interval, P-wave duration, atrial-His interval, His-ventricular interval) have important clinical implications and raise special therapeutic considerations in the management of arrhythmias in women. Although data so far suggest that the gonadal sex hormones are key in the mechanisms that underlie the sex differences in human electrophysiology, other mechanisms that are independent of the sex hormones probably exist. While data (particularly from animal models) have provided insight into the sex differences, further work is needed to fully elucidate the underlying mechanisms.

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