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Central Sensitization Syndrome: The Role of Microglia in Chronic Pain and Depression 

Central Sensitization Syndrome: The Role of Microglia in Chronic Pain and Depression
Chapter:
Central Sensitization Syndrome: The Role of Microglia in Chronic Pain and Depression
Author(s):

Gary Kaplan

DOI:
10.1093/med/9780199315246.003.0006
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date: 19 June 2019

Given the frequency of the comorbidity of chronic pain and other neuropsychiatric conditions it is not surprising that these diseases share overlapping pathophysiologic processes in the central nervous system. This chapter discusses how both conditions demonstrate neuronal dysregulation of common neuroanatomical structures with resultant evidence of neuronal degeneration in these regions and disruption of neuroendocrine processes. Of greatest importance is a growing body of evidence that chronic pain and many neuropsychiatric conditions are neuroinflammatory and are neuroimmunologically mediated.

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