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Hormones and Pain 

Hormones and Pain
Hormones and Pain

Forest Tennent

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date: 23 October 2021

Severe pain has profound physiologic effects on the hormonal system. Acute pain causes hyperarousal of the hypothalamic-pituitary-adrenal system with chronic refractory pain creating the potential for deficiency states. Hormone deficiency states may exacerbate pain comorbidities such as depression and increase metabolic syndrome. Daily opioid administration may suppress multiple hormones including testosterone and may require monitoring and replacement to reduce longterm consequences.

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