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date: 01 March 2021

Classification 444

Presentation 446

Investigations 447

Staging and treatment 448

Post-transplant lymphoproliferative disorders 450

Leukaemia and lymphoma account for 30 and 15%, respectively, of childhood malignancies.

What is the difference between acute lymphocytic leukaemia and lymphoma? Historically, the distinction arose based on the clinical presentation with either bone marrow failure (leukaemia) or lymphadenopathy (lymphoma). This led to treatment developing along separate pathways until it began to be appreciated in the 1980s that it was the stage of differentiation arrest of the malignant lymphocyte precursor, rather than the distribution of disease, that was crucial, and that some lymphomas responded better to leukaemia-type treatment and ...

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