Acute myeloid leukaemia
- DOI:
- 10.1093/med/9780199299676.003.27
Epidemiology 406
Aetiology 407
Clinical presentation 408
Investigations 409
Diagnosis 409
Classification 410
Risk stratification 413
Treatment 414
Prognosis 418
The future 418
Acute myeloid leukaemia (AML) comprises a group of clonal disorders caused by maturation arrest leading to proliferation of abnormal myeloid precursor cells. However, this definition incorporates a wide and heterogenous group of leukaemias (see Classification). The prognosis of paediatric AML was very poor until the introduction of intensive chemotherapy protocols in the 1980s, but has now improved greatly although survival rates still lag behind those for ALL....
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