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Acute myeloid leukaemia 

Acute myeloid leukaemia
Chapter:
Acute myeloid leukaemia
DOI:
10.1093/med/9780199299676.003.27
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date: 14 October 2019

Epidemiology 406

Aetiology 407

Clinical presentation 408

Investigations 409

Diagnosis 409

Classification 410

Risk stratification 413

Treatment 414

Prognosis 418

The future 418

Acute myeloid leukaemia (AML) comprises a group of clonal disorders caused by maturation arrest leading to proliferation of abnormal myeloid precursor cells. However, this definition incorporates a wide and heterogenous group of leukaemias (see Classification). The prognosis of paediatric AML was very poor until the introduction of intensive chemotherapy protocols in the 1980s, but has now improved greatly although survival rates still lag behind those for ALL....

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