Show Summary Details
Page of

Infection 

Infection
Chapter:
Infection
DOI:
10.1093/med/9780199299676.003.17
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2016. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 23 October 2019

Historical perspective 208

Epidemiology 210

Pathogenesis and risk factors 212

Prevention of infection 214

Febrile neutropenia 216

System specific infections 220

The high mortality rate in febrile neutropenia became apparent following the pioneering early experience with chemotherapy in the treatment of childhood malignancies [e.g. acute lymphoblastic leukaemia (ALL), Wilms’ tumour) in the late 1950s and 1960s. Subsequently, during the 1970s this mortality was reduced by the early use of empirical antibiotic treatment in any febrile neutropenic child, even in the absence of any additional clinical (e.g. signs of systemic sepsis or focal infection) or microbiological evidence of infection. Numerous different empirical protocols have been developed, usually guided by a knowledge of local bacterial and antibiotic resistance patterns....

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.