Show Summary Details
Page of

Oxycodone 

Oxycodone
Chapter:
Oxycodone
Author(s):

Paul Glare

and Mellar P. Davis

DOI:
10.1093/med/9780199236640.003.0010
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2020. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 31 March 2020

Chapter 10 discusses Oxycodone (14-hydroxy-7,8-di-hydrocodeinone), a semi-synthetic derivative of the opium alkaloid thebaine. Oxycodone has been in clinical use for almost 100 years and is classified as a step 2 or weak opioid. In 1981, single-agent oxycodone became available in the USA. The availability of oxycodone without a NSAID enabled escalation of the dose and use for more severe pain, and it was reclassified as a step 3 strong opioid without dose limitations. In 1996, a sustained-release (SR) doublematrix product became commercially available for patient convenience and compliance was improved. The SR formulation has led to a rapid increase in the prescribing of oxycodone as an alternative to morphine. The studies of oxycodone undertaken in the 1990s indicate that it is as effective as morphine, and there has been speculation that it has a better adverse effect profile. Few new clinical studies of this old drug have been published in recent years, but its pharmacology is becoming better understood.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.