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Mellar P. Davis

and Paul Glare

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date: 24 September 2021

Chapter 7 discusses Tramadol and its use as the most frequently used step 2 opioid (based on the World Health Organization Analgesic Guidelines) in the world. It is available in over 100 countries, which may be in part due to the low abuse and addiction potential of this drug. Tramadol analgesia depends in part on the pharmacogenetics of the cytochrome CYP2D6 which differs in various populations of the world. As a result, the benefits of tramadol may differ regionally.

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