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Mellar P. Davis

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date: 17 September 2021

Chapter 6 discusses hydrocodone (dihydrocodeinone), a semi-synthetic congener of codeine, which has a greater affinity for mu receptors than codeine. In certain animal models, the antinociceptive response per dose is equivalent to that of morphine. Commercially, hydrocodone is available only as a compounded analgesic with either ibuprofen or paracetamol (acetaminophen), which limits its doses escalation and artificially renders hydrocodone a ‘weak’ opioid. It also covers the recent abuse and misuse of hydrocodone in the USA that has exceeded that of most other opioids, including oxycodone, and which may influence prescribing habits.

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