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Hydrocodone 

Hydrocodone
Chapter:
Hydrocodone
Author(s):

Mellar P. Davis

DOI:
10.1093/med/9780199236640.003.0006
Page of

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date: 24 October 2020

Chapter 6 discusses hydrocodone (dihydrocodeinone), a semi-synthetic congener of codeine, which has a greater affinity for mu receptors than codeine. In certain animal models, the antinociceptive response per dose is equivalent to that of morphine. Commercially, hydrocodone is available only as a compounded analgesic with either ibuprofen or paracetamol (acetaminophen), which limits its doses escalation and artificially renders hydrocodone a ‘weak’ opioid. It also covers the recent abuse and misuse of hydrocodone in the USA that has exceeded that of most other opioids, including oxycodone, and which may influence prescribing habits.

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