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Opioid pharmacokinetics 

Opioid pharmacokinetics
Opioid pharmacokinetics

Kenneth C. Jackson II

, Mellar P. Davis

, and Columba Quigley

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date: 23 September 2021

Chapter 2 discusses the disposition of an individual opioid from the point of initial administration to a patient. Four distinct phases are considered within the scope of pharmacokinetics: absorption, distribution, metabolism, and elimination. Of note, these parameters impact the effectiveness of opioids and other analgesics when administered via any route currently used to provide analgesia. While not unique to opioids, the availability of a variety of elegantly formulated controlled release dosage preparations adds an additional dimension for consideration.

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