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The endometrium: receptivity, implantation, and endometrial cancer as endocrine disease 

The endometrium: receptivity, implantation, and endometrial cancer as endocrine disease
Chapter:
The endometrium: receptivity, implantation, and endometrial cancer as endocrine disease
Author(s):

Markku Seppälä

and Linda C. Giudice

DOI:
10.1093/med/9780199235292.003.0892
Page of

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date: 26 June 2019

In biological terms, human life is a continuum in which male and female gametes fuse in fertilization (conception) to form an embryo. Usually fertilization takes place in the distal part of fallopian tube where the embryo remains 2–3 days, dividing at 12–15 h intervals. On day 3 the embryo has 8 cells, on day 4 a morula stage has been reached, and on day 5 the embryo forms a blastocyst and enters the uterus. The embryo hatches before it implants in the endometrium, most implantations (86%) occurring between day LH +8 and day LH +11 (1). The most reliable clinical sign of implantation is secretion of human chorionic gonadotropin (hCG) from the embryonic trophoblast into maternal serum and urine.

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