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Polycystic ovary syndrome: metabolic aspects 

Polycystic ovary syndrome: metabolic aspects
Chapter:
Polycystic ovary syndrome: metabolic aspects
Author(s):

Richard S. Legro

DOI:
10.1093/med/9780199235292.003.0857
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date: 28 September 2021

Polycystic ovary syndrome (PCOS) is thought to be primarily a disorder that affects women during their reproductive years. The diagnostic criteria reflect ovarian dysfunction, i.e. hyperandrogenism, anovulation, and polycystic ovaries. However, women with PCOS appear to be uniquely insulin resistant, are frequently obese, and may be at risk for a variety of long-term health disorders including diabetes, cardiovascular disease, and cancers. Although the endocrine and reproductive features of the disorder improve with age, the associated metabolic abnormalities, particularly components of the metabolic syndrome, may actually worsen. This chapter will explore the pathophysiology of aberrant insulin action in women with PCOS, recognition of long-term risks, and preventive strategies.

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