Contents

Disclaimer

Oxford University Press makes no representation, express or implied, that the drug dosages in this book are correct. Readers must therefore always check the product information and clinical procedures with the most up to date published product information and data sheets provided by the manufacturers and the most recent codes of conduct and safety regulations. The authors and the publishers do not accept responsibility or legal liability for any errors in the text or for the misuse or misapplication of material in this work. Except where otherwise stated, drug dosages and recommendations are for the non-pregnant adult who is not breastfeeding.

Show Summary Details
Page of

Systemic mastocytosis 

Systemic mastocytosis
Chapter:
Systemic mastocytosis
Author(s):

Tomás Ahern

and Donal O’Shea

DOI:
10.1093/med/9780199235292.003.0671
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2021. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 17 October 2021

Mastocytosis is a heterogeneous group of rare disorders characterized by the abnormal growth and accumulation of mast cells in one or more organs. Mast cells are myeloid lineage cells that express the CD117 (KIT), CD45, and Fcε‎RI cell surface markers. Patients with mastocytosis often present with abdominal cramps and diarrhoea and episodes of flushing, lightheadedness, and headache, which may prompt investigation for a neuroendocrine cause.

Cutaneous manifestations are common to all forms of mastocytosis. The majority of cases of mastocytosis are relatively benign, although some forms are associated with significant early death. The clinical course of mastocytosis is variable and can include shifting between the different forms.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.