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Insulinoma and hypoglycaemia 

Insulinoma and hypoglycaemia
Chapter:
Insulinoma and hypoglycaemia
Author(s):

Puja Mehta

and Jeannie F. Todd

DOI:
10.1093/med/9780199235292.003.0643
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date: 02 December 2020

Hypoglycaemia is a clinical syndrome with diverse aetiology. Insulinomas, although rare, are the most common functioning pancreatic islet cell tumour and may be part of the multiple endocrine neoplasia type 1 (MEN 1) syndrome. Patients present with symptoms of neuroglycopenia and a catecholamine response. Diagnosis is confirmed by evidence of endogenous hyperinsulinaemic hypoglycaemia. Tumours are localized by ultrasonography, CT and/or intra-arterial calcium stimulation with venous sampling. Most tumours are benign and solitary, making surgical cure possible with complete resection. Medical options, including diazoxide or octreotide, are available for multifocal tumours.

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