- Part 1 Principles of international endocrine practice
- Part 2 Pituitary and hypothalamic diseases
- Part 3 The thyroid
- Part 4 Parathyroid, calcium, and bone metabolism
- Part 5 The adrenal gland and endocrine hypertension
- Part 6 Neuroendocrine tumours and genetic disorders
- 6.1 Neuroendocrine tumours of the gastrointestinal tract: an appraisal of the past and perspectives for the future
- 6.2 Neuroendocrine tumour markers
- 6.3 Neuroendocrine (carcinoid) tumours and the carcinoid syndrome
- 6.4 Gastrinoma
- 6.5 Insulinoma and hypoglycaemia
- 6.6 Glucagonoma
- 6.7 VIPomas
- 6.8 Somatostatinoma
- 6.9 Imaging neuroendocrine tumours of the gastrointestinal tract
- 6.10 Systemic mastocytosis
- 6.11 Multiple endocrine neoplasia type 1
- 6.12 Multiple endocrine neoplasia type 2
- 6.13 von Hippel–Lindau disease and succinate dehydrogenase subunit (SDHB, SDHC, and SDHD) genes
- 6.14 Neurofibromatosis
- 6.15 Carney’s complex
- 6.16 Molecular and clinical characteristics of the McCune–Albright syndrome
- 6.17 Cowden’s syndrome
- Part 7 Growth and development during childhood
- Part 8 Female endocrinology and pregnancy
- Part 9 Male hypogonadism and infertility
- Part 10 Endocrinology of ageing and systemic disease
- Part 11 Endocrinology of cancer
- Part 12 Obesity, lipids, and metabolic disorders
- Part 13 Diabetes mellitus
(p. 901) Neuroendocrine (carcinoid) tumours and the carcinoid syndrome
- Chapter:
- (p. 901) Neuroendocrine (carcinoid) tumours and the carcinoid syndrome
- Author(s):
Rajaventhan Srirajaskanthan
, Martyn E. Caplin
, and Humphrey Hodgson
- DOI:
- 10.1093/med/9780199235292.003.0628
Neuroendocrine tumours (NETs) are derived from cells of the diffuse neuroendocrine system, which are present in organs throughout the body. Originally, Pearse proposed that tumours develop from migration of cells from the neural crest; however, it is now thought that the tumour cells are derived from multipotent stem cells (1).
The term ‘karzinoide’ (meaning carcinoma like) was initially introduced by Siegfried Oberndorfer in 1907 (2). The term carcinoid tumour has historically been used; however, with advances in the understanding of the tumour biology, and the recent WHO classification, the term NET or endocrine tumour is considered more appropriate, and more details are given in the historical introduction in Chapter 6.1.
Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.
Please subscribe or login to access full text content.
If you have purchased a print title that contains an access token, please see the token for information about how to register your code.
For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.
- Part 1 Principles of international endocrine practice
- Part 2 Pituitary and hypothalamic diseases
- Part 3 The thyroid
- Part 4 Parathyroid, calcium, and bone metabolism
- Part 5 The adrenal gland and endocrine hypertension
- Part 6 Neuroendocrine tumours and genetic disorders
- 6.1 Neuroendocrine tumours of the gastrointestinal tract: an appraisal of the past and perspectives for the future
- 6.2 Neuroendocrine tumour markers
- 6.3 Neuroendocrine (carcinoid) tumours and the carcinoid syndrome
- 6.4 Gastrinoma
- 6.5 Insulinoma and hypoglycaemia
- 6.6 Glucagonoma
- 6.7 VIPomas
- 6.8 Somatostatinoma
- 6.9 Imaging neuroendocrine tumours of the gastrointestinal tract
- 6.10 Systemic mastocytosis
- 6.11 Multiple endocrine neoplasia type 1
- 6.12 Multiple endocrine neoplasia type 2
- 6.13 von Hippel–Lindau disease and succinate dehydrogenase subunit (SDHB, SDHC, and SDHD) genes
- 6.14 Neurofibromatosis
- 6.15 Carney’s complex
- 6.16 Molecular and clinical characteristics of the McCune–Albright syndrome
- 6.17 Cowden’s syndrome
- Part 7 Growth and development during childhood
- Part 8 Female endocrinology and pregnancy
- Part 9 Male hypogonadism and infertility
- Part 10 Endocrinology of ageing and systemic disease
- Part 11 Endocrinology of cancer
- Part 12 Obesity, lipids, and metabolic disorders
- Part 13 Diabetes mellitus