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Neuroendocrine (carcinoid) tumours and the carcinoid syndrome 

Neuroendocrine (carcinoid) tumours and the carcinoid syndrome
Chapter:
Neuroendocrine (carcinoid) tumours and the carcinoid syndrome
Author(s):

Rajaventhan Srirajaskanthan

, Martyn E. Caplin

, and Humphrey Hodgson

DOI:
10.1093/med/9780199235292.003.0628
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date: 20 May 2022

Neuroendocrine tumours (NETs) are derived from cells of the diffuse neuroendocrine system, which are present in organs throughout the body. Originally, Pearse proposed that tumours develop from migration of cells from the neural crest; however, it is now thought that the tumour cells are derived from multipotent stem cells (1).

The term ‘karzinoide’ (meaning carcinoma like) was initially introduced by Siegfried Oberndorfer in 1907 (2). The term carcinoid tumour has historically been used; however, with advances in the understanding of the tumour biology, and the recent WHO classification, the term NET or endocrine tumour is considered more appropriate, and more details are given in the historical introduction in Chapter 6.1.

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