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Paget’s disease of bone 

Paget’s disease of bone
Chapter:
Paget’s disease of bone
Author(s):

Socrates E. Papapoulos

DOI:
10.1093/med/9780199235292.003.0471
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date: 19 June 2019

In 1876, Sir James Paget presented to the Royal Medical and Chirurgical Society of London an account of his experience with a previously unrecognized disease of the skeleton, which he termed osteitis deformans and has since born his name. Paget’s disease of bone is a focal skeletal disorder which progresses slowly and leads to changes in the shape and size of affected bones and to skeletal, articular, and vascular complications. In some parts of the world it is the second most common bone disorder after osteoporosis. The disease is easily diagnosed and effectively treated but its pathogenesis is largely unknown (1–3).

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