- Part 1 Principles of international endocrine practice
- Part 2 Pituitary and hypothalamic diseases
- Part 3 The thyroid
- Part 4 Parathyroid, calcium, and bone metabolism
- 4.1 Parathyroid anatomy, hormone synthesis, secretion, action, and receptors
- 4.2Hypercalcaemia
- 4.3 Primary hyperparathyroidism
- 4.4 Familial hypocalciuric hypercalcaemia
- 4.5 Hypocalcaemic disorders, hypoparathyroidism, and pseudohypoparathyroidism
- 4.6 Hypercalcaemic and hypocalcaemic syndromes in children
- 4.7 Osteoporosis
- 4.8 Thyroid disorders and bone disease
- 4.9 Paget’s disease of bone
- 4.10 Rickets and osteomalacia (acquired and heritable forms) and skeletal dysplasias
- 4.11 Glucocorticoid-induced osteoporosis
- Part 5 The adrenal gland and endocrine hypertension
- Part 6 Neuroendocrine tumours and genetic disorders
- Part 7 Growth and development during childhood
- Part 8 Female endocrinology and pregnancy
- Part 9 Male hypogonadism and infertility
- Part 10 Endocrinology of ageing and systemic disease
- Part 11 Endocrinology of cancer
- Part 12 Obesity, lipids, and metabolic disorders
- Part 13 Diabetes mellitus
(p. 721) Paget’s disease of bone
- Chapter:
- (p. 721) Paget’s disease of bone
- Author(s):
Socrates E. Papapoulos
- DOI:
- 10.1093/med/9780199235292.003.0471
In 1876, Sir James Paget presented to the Royal Medical and Chirurgical Society of London an account of his experience with a previously unrecognized disease of the skeleton, which he termed osteitis deformans and has since born his name. Paget’s disease of bone is a focal skeletal disorder which progresses slowly and leads to changes in the shape and size of affected bones and to skeletal, articular, and vascular complications. In some parts of the world it is the second most common bone disorder after osteoporosis. The disease is easily diagnosed and effectively treated but its pathogenesis is largely unknown (1–3).
Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.
Please subscribe or login to access full text content.
If you have purchased a print title that contains an access token, please see the token for information about how to register your code.
For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.
- Part 1 Principles of international endocrine practice
- Part 2 Pituitary and hypothalamic diseases
- Part 3 The thyroid
- Part 4 Parathyroid, calcium, and bone metabolism
- 4.1 Parathyroid anatomy, hormone synthesis, secretion, action, and receptors
- 4.2Hypercalcaemia
- 4.3 Primary hyperparathyroidism
- 4.4 Familial hypocalciuric hypercalcaemia
- 4.5 Hypocalcaemic disorders, hypoparathyroidism, and pseudohypoparathyroidism
- 4.6 Hypercalcaemic and hypocalcaemic syndromes in children
- 4.7 Osteoporosis
- 4.8 Thyroid disorders and bone disease
- 4.9 Paget’s disease of bone
- 4.10 Rickets and osteomalacia (acquired and heritable forms) and skeletal dysplasias
- 4.11 Glucocorticoid-induced osteoporosis
- Part 5 The adrenal gland and endocrine hypertension
- Part 6 Neuroendocrine tumours and genetic disorders
- Part 7 Growth and development during childhood
- Part 8 Female endocrinology and pregnancy
- Part 9 Male hypogonadism and infertility
- Part 10 Endocrinology of ageing and systemic disease
- Part 11 Endocrinology of cancer
- Part 12 Obesity, lipids, and metabolic disorders
- Part 13 Diabetes mellitus