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Clinical assessment and systemic manifestations of hypothyroidism 

Clinical assessment and systemic manifestations of hypothyroidism
Clinical assessment and systemic manifestations of hypothyroidism

Massimo Tonacchera

, Luca Chiovato

, and Aldo Pinchera

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date: 19 May 2022

Hypothyroidism may affect people of both sexes and all ages. The clinical expression of thyroid hormone deficiency varies considerably between individuals. It is influenced mainly by the age of the patient and the rate at which hypothyroidism develops although being largely independent of its cause. Most adult patients complain of a slowing of physical and mental activity.

Hypothyroidism is a graded phenomenon, ranging from very mild cases, in which biochemical abnormalities (subclinical hypothyroidism; see Chapter 3.4.4) are present but the individual hardly notices symptoms and signs of thyroid hormone deficiency, to very severe cases in which the danger exists of sliding down into a life-threatening myxoedema coma.

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