- Part 1 Principles of international endocrine practice
- Part 2 Pituitary and hypothalamic diseases
- Part 3 The thyroid
- 3.1 Evaluation of the thyroid patient
- 3.2 Aetiology of thyroid disorders
- 3.3 Thyrotoxicosis and related disorders
- 3.3.1 Clinical assessment and systemic manifestations of thyrotoxicosis
- 3.3.2 Thyrotoxic periodic paralysis
- 3.3.3 Thyrotoxic storm
- 3.3.4 Subclinical hyperthyroidism
- 3.3.5 Causes and laboratory investigations of thyrotoxicosis
- 3.3.6 Antithyroid drug treatment for thyrotoxicosis
- 3.3.7 Radio-iodine treatment of hyperthyroidism
- 3.3.8 Surgery for thyrotoxicosis
- 3.3.9 Management of Graves’ hyperthyroidism
- 3.3.10 Graves’ ophthalmopathy and dermopathy
- 3.3.11 Management of toxic multinodular goitre and toxic adenoma
- 3.3.12 Management of thyrotoxicosis without hyperthyroidism
- 3.4 Hypothyroidism and pregnancy- and growth-related thyroid disorders
- 3.5 Thyroid lumps
- Part 4 Parathyroid, calcium, and bone metabolism
- Part 5 The adrenal gland and endocrine hypertension
- Part 6 Neuroendocrine tumours and genetic disorders
- Part 7 Growth and development during childhood
- Part 8 Female endocrinology and pregnancy
- Part 9 Male hypogonadism and infertility
- Part 10 Endocrinology of ageing and systemic disease
- Part 11 Endocrinology of cancer
- Part 12 Obesity, lipids, and metabolic disorders
- Part 13 Diabetes mellitus
Thyrotoxic periodic paralysis
- Chapter:
- Thyrotoxic periodic paralysis
- Author(s):
Annie W.C. Kung
- DOI:
- 10.1093/med/9780199235292.003.3171
The association of thyrotoxicosis and periodic paralysis was first described in 1902 in a white patient. However, it soon became evident that thyrotoxic periodic paralysis (TPP) affects mainly Asian populations, in particular Chinese and Japanese, although isolated cases have also been reported in other ethnic groups such as white, Hispanic, African-American, and American Indian populations. The incidence of TPP in non-Asian thyrotoxic patients is around 0.1%, whereas in Chinese and Japanese thyrotoxic patients, TPP affects 1.8% and 1.9%, respectively (1–3). Despite a higher incidence of thyrotoxicosis in women, TPP affects mainly men, with a male to female ratio ranging from 17:1 to 70:1, according to different series. In the Chinese population, TPP affects 13% of male and 0.17% of female thyrotoxic patients. In the Japanese population, TPP was reported to occur in 8.2% of male and 0.4% of female thyrotoxic patients in the 1970s, but in 1991 the reported incidence had decreased to 4.3% and 0.04%, respectively (4).
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- Part 1 Principles of international endocrine practice
- Part 2 Pituitary and hypothalamic diseases
- Part 3 The thyroid
- 3.1 Evaluation of the thyroid patient
- 3.2 Aetiology of thyroid disorders
- 3.3 Thyrotoxicosis and related disorders
- 3.3.1 Clinical assessment and systemic manifestations of thyrotoxicosis
- 3.3.2 Thyrotoxic periodic paralysis
- 3.3.3 Thyrotoxic storm
- 3.3.4 Subclinical hyperthyroidism
- 3.3.5 Causes and laboratory investigations of thyrotoxicosis
- 3.3.6 Antithyroid drug treatment for thyrotoxicosis
- 3.3.7 Radio-iodine treatment of hyperthyroidism
- 3.3.8 Surgery for thyrotoxicosis
- 3.3.9 Management of Graves’ hyperthyroidism
- 3.3.10 Graves’ ophthalmopathy and dermopathy
- 3.3.11 Management of toxic multinodular goitre and toxic adenoma
- 3.3.12 Management of thyrotoxicosis without hyperthyroidism
- 3.4 Hypothyroidism and pregnancy- and growth-related thyroid disorders
- 3.5 Thyroid lumps
- Part 4 Parathyroid, calcium, and bone metabolism
- Part 5 The adrenal gland and endocrine hypertension
- Part 6 Neuroendocrine tumours and genetic disorders
- Part 7 Growth and development during childhood
- Part 8 Female endocrinology and pregnancy
- Part 9 Male hypogonadism and infertility
- Part 10 Endocrinology of ageing and systemic disease
- Part 11 Endocrinology of cancer
- Part 12 Obesity, lipids, and metabolic disorders
- Part 13 Diabetes mellitus