- Part 1 Principles of international endocrine practice
- Part 2 Pituitary and hypothalamic diseases
- 2.1 General concepts of hypothalamus-pituitary anatomy
- 2.2 The neurohypophysis
- 2.3 Aetiology, pathogenesis, and management of disease of the pituitary
- 2.3.1 Development of the pituitary and genetic forms of hypopituitarism
- 2.3.2 Molecular pathogenesis of pituitary tumours
- 2.3.3 Histopathology of pituitary tumours
- 2.3.4 Pituitary assessment strategy
- 2.3.5 Imaging of the pituitary
- 2.3.6 Hypopituitarism: replacement of adrenal, thyroid, and gonadal axes
- 2.3.7 Adult growth hormone deficiency
- 2.3.8 Surgery of pituitary tumours
- 2.3.9 Pituitary radiotherapy
- 2.3.10 Prolactinomas and hyperprolactinaemia (including macroprolactinaemia)
- 2.3.11 Acromegaly
- 2.3.12 Clinically nonfunctioning pituitary tumours and gonadotropinomas
- 2.3.13 Thyrotropinomas
- 2.3.14 Pituitary carcinoma
- 2.3.15 Pituitary incidentalomas
- 2.4 Aetiology, pathogenesis, and management of diseases of the hypothalamus
- 2.5 Pineal physiology and pathophysiology, including pineal tumours
- 2.6 Neuropsychiatric endocrinological disorders
- Part 3 The thyroid
- Part 4 Parathyroid, calcium, and bone metabolism
- Part 5 The adrenal gland and endocrine hypertension
- Part 6 Neuroendocrine tumours and genetic disorders
- Part 7 Growth and development during childhood
- Part 8 Female endocrinology and pregnancy
- Part 9 Male hypogonadism and infertility
- Part 10 Endocrinology of ageing and systemic disease
- Part 11 Endocrinology of cancer
- Part 12 Obesity, lipids, and metabolic disorders
- Part 13 Diabetes mellitus
Surgery of pituitary tumours
- Chapter:
- Surgery of pituitary tumours
- Author(s):
Ian F. Dunn
and Edward R. Laws
- DOI:
- 10.1093/med/9780199235292.003.2098
Pituitary tumours have both endocrine and neuro-oncologic sequelae. Secretory tumours may liberate physiological hormones to pathological excess, generating a full spectrum of metabolic aberrations and hallmark clinical syndromes. Other pituitary tumours are endocrinologically inactive and generate instead a variety of compressive phenomena such as pituitary hypofunction and neurological compromise. Although advances continue to be made in the pharmacological and radiotherapeutic management of pituitary tumours, surgery remains the treatment of choice for most of these lesions. Of the available surgical options, the transsphenoidal route is the dominant surgical approach to these tumours. Shaped by the brilliant insight of individual surgeons and technological innovation, transsphenoidal surgery for the sellar and parasellar regions is a fascinating chronicle in surgical history whose evolution continues unabated. We herein review surgical approaches to pituitary tumours, emphasizing the transsphenoidal approach.
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- Part 1 Principles of international endocrine practice
- Part 2 Pituitary and hypothalamic diseases
- 2.1 General concepts of hypothalamus-pituitary anatomy
- 2.2 The neurohypophysis
- 2.3 Aetiology, pathogenesis, and management of disease of the pituitary
- 2.3.1 Development of the pituitary and genetic forms of hypopituitarism
- 2.3.2 Molecular pathogenesis of pituitary tumours
- 2.3.3 Histopathology of pituitary tumours
- 2.3.4 Pituitary assessment strategy
- 2.3.5 Imaging of the pituitary
- 2.3.6 Hypopituitarism: replacement of adrenal, thyroid, and gonadal axes
- 2.3.7 Adult growth hormone deficiency
- 2.3.8 Surgery of pituitary tumours
- 2.3.9 Pituitary radiotherapy
- 2.3.10 Prolactinomas and hyperprolactinaemia (including macroprolactinaemia)
- 2.3.11 Acromegaly
- 2.3.12 Clinically nonfunctioning pituitary tumours and gonadotropinomas
- 2.3.13 Thyrotropinomas
- 2.3.14 Pituitary carcinoma
- 2.3.15 Pituitary incidentalomas
- 2.4 Aetiology, pathogenesis, and management of diseases of the hypothalamus
- 2.5 Pineal physiology and pathophysiology, including pineal tumours
- 2.6 Neuropsychiatric endocrinological disorders
- Part 3 The thyroid
- Part 4 Parathyroid, calcium, and bone metabolism
- Part 5 The adrenal gland and endocrine hypertension
- Part 6 Neuroendocrine tumours and genetic disorders
- Part 7 Growth and development during childhood
- Part 8 Female endocrinology and pregnancy
- Part 9 Male hypogonadism and infertility
- Part 10 Endocrinology of ageing and systemic disease
- Part 11 Endocrinology of cancer
- Part 12 Obesity, lipids, and metabolic disorders
- Part 13 Diabetes mellitus