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John A. H. Wass

, Peter J. Trainer

, and Márta Korbonits

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date: 26 January 2022

Acromegaly is the condition most often associated with an anterior pituitary tumour, which results from growth hormone and insulin-like growth factor 1 (IGF-1) excess. It causes most characteristically enlargement of the hands and feet (Greek: akron, extremities; megas, great). Gigantism, which is the juvenile counterpart of acromegaly, is also caused by a pituitary tumour secreting growth hormone, but it causes excessive growth before epiphyseal fusion. It occurs less frequently than acromegaly because pituitary tumours in children are much less common than in adults.

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