Contents

Disclaimer

Oxford University Press makes no representation, express or implied, that the drug dosages in this book are correct. Readers must therefore always check the product information and clinical procedures with the most up to date published product information and data sheets provided by the manufacturers and the most recent codes of conduct and safety regulations. The authors and the publishers do not accept responsibility or legal liability for any errors in the text or for the misuse or misapplication of material in this work. Except where otherwise stated, drug dosages and recommendations are for the non-pregnant adult who is not breastfeeding.

Show Summary Details
Page of

Development of the pituitary and genetic forms of hypopituitarism 

Development of the pituitary and genetic forms of hypopituitarism
Chapter:
Development of the pituitary and genetic forms of hypopituitarism
Author(s):

Kyriaki S. Alatzoglou

and Mehul T. Dattani

DOI:
10.1093/med/9780199235292.003.2040
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2020. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 25 October 2020

Pituitary development occurs in distinct and sequential developmental steps, leading to the formation of a complex organ containing five different cell types secreting six different hormones. During this process the sequential temporal and spatial expression of a cascade of signalling molecules and transcription factors play a crucial role in organ commitment, cell proliferation, patterning, and terminal differentiation. Complex regulatory networks govern the process during which distinct cell types emerge from a common primordium. The mechanisms are not fully elucidated but it seems that opposing signalling gradients induce expression of interacting transcriptional regulators (activators or repressors) in overlapping patterns that act synergistically. Spontaneous or artificially induced mutations in the mouse and identification of mutations associated with human pituitary disease have contributed to defining the genetic cascades responsible for pituitary development.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.