Show Summary Details
Page of

Metabolic syndrome 

Metabolic syndrome
Metabolic syndrome

Harold E. Lebovitz

Page of

PRINTED FROM OXFORD MEDICINE ONLINE ( © Oxford University Press, 2022. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 19 May 2022

The metabolic syndrome (MetS) has been recognized as a clinical entity for more than 50 years. In 1947, Vague described upper body obesity as a predisposing factor in the development of diabetes mellitus, atherosclerosis, and gout. Reaven, in his 1988 Banting lecture, focused on the importance of insulin resistance and a related cluster of metabolic abnormalities that were associated with an increase in coronary artery disease (1). This cluster included resistance to insulin-stimulated glucose uptake, glucose intolerance, hyperinsulinaemia, increased very-low-density lipoprotein (VLDL) triglyceride, decreased high-density lipoprotein (HDL) cholesterol, and hypertension. He called this cluster ‘syndrome X’, and raised the possibility that resistance to insulin-stimulated glucose uptake and hyperinsulinaemia were involved in the aetiology of the metabolic abnormalities and the clinical diseases associated with them. Obesity and, particularly, visceral obesity have been recognized as a major contributor to the MetS since precise techniques to quantitate regional body composition became available. The MetS was initially thought of as an insulin resistance syndrome, implying that insulin resistance was the underlying unifying abnormality.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.