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Late effects of cancer treatment 

Late effects of cancer treatment
Chapter:
Late effects of cancer treatment
Author(s):

Andrew A. Toogood

DOI:
10.1093/med/9780199235292.003.7133
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date: 15 November 2019

In the last 40 years there has been a dramatic improvement in the treatment of malignant disease, particularly during childhood. The multidisciplinary approach to patient management utilizing various combinations of chemotherapeutic agents and, when appropriate, surgery, and radiotherapy has resulted in a rise in the overall survival rate from childhood cancer from 23% in the 1960s to 75% today. Acute lymphoblastic leukaemia (ALL) is cured in 81% of cases and for Hodgkin’s lymphoma and germ cell tumours cure is now achieved in excess of 90% of cases. (Fig. 7.4.1) It has been estimated that 1:715 young adults is a survivor of childhood cancer. The success seen in paediatric oncology is now being mirrored in adult oncology, particularly amongst younger adults; it is estimated that 2 million adults in the United Kingdom have been treated for and survived cancer.

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