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Management of thyrotoxicosis without hyperthyroidism 

Management of thyrotoxicosis without hyperthyroidism
Management of thyrotoxicosis without hyperthyroidism

Wilmar M. Wiersinga

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date: 26 May 2022

Thyrotoxicosis without hyperthyroidism is a condition of thyroid hormone excess not caused by increased biosynthesis of thyroid hormones in the thyroid gland. The thyroid hormone excess in such cases originates either from the thyroid gland as a result of destructive lesions or from extrathyroidal sources. The hallmark of thyrotoxicosis without hyperthyroidism is a low uptake of radio-iodine in the neck (see Chapter 3.3.5). Cytokine-, iodine-, and amiodarone-induced thyrotoxicosis manifest themselves either as thyrotoxicosis without hyperthyroidism, or as thyrotoxicosis with hyperthyroidism in which thyroidal radio-iodine uptake is preserved. Both types are discussed in this chapter.

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