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Contents
- Front Matter
- Part 1 Principles of international endocrine practice
- 1.1 A brief history of endocrinology Robert Arnott
- 1.2 Prevention in endocrinology Peter Laurberg, Stig Andersen
- 1.3 Endocrinology and evolution: lessons from comparative endocrinology Janine A. Danks, Samantha J. Richardson
- 1.4 Hormones and receptors: fundamental considerations John W. Funder
- 1.5 Molecular aspects of hormonal regulation Shern L. Chew
- 1.6 Endocrine autoimmunity Matthew J. Simmonds, Stephen C. L. Gough
- 1.7 Measurement of hormones Mike Wallace
- 1.8 Endocrine disruptors George Creatsas, George Mastorakos
- 1.9 Sports endocrinology: the use and abuse of performance-enhancing hormones and drugs Leonard John Deftos and Mark Zeigler
- Part 2 Pituitary and hypothalamic diseases
- 2.1 General concepts of hypothalamus-pituitary anatomy Ignacio Bernabeu, Monica Marazuela, Felipe F. Casanueva
- 2.2 The neurohypophysis Stephen G. Ball
- 2.3 Aetiology, pathogenesis, and management of disease of the pituitary
- 2.3.1 Development of the pituitary and genetic forms of hypopituitarism Kyriaki S. Alatzoglou, Mehul T. Dattani
- 2.3.2 Molecular pathogenesis of pituitary tumours Ines Donangelo, Shlomo Melmed
- 2.3.3 Histopathology of pituitary tumours Eva Horvath, Kalman Kovacs
- 2.3.4 Pituitary assessment strategy W. M. Drake, P. J. Trainer
- 2.3.5 Imaging of the pituitary J. V. Byrne
- 2.3.6 Hypopituitarism: replacement of adrenal, thyroid, and gonadal axes Trevor A. Howlett
- 2.3.7 Adult growth hormone deficiency Aurora Aragon-Alonso, Mark Sherlock, Andrew A. Toogood
- 2.3.8 Surgery of pituitary tumours Ian F. Dunn, Edward R. Laws Jr.
- 2.3.9 Pituitary radiotherapy Thankamma Ajithkumar, Michael Brada
- 2.3.10 Prolactinomas and hyperprolactinaemia (including macroprolactinaemia) John S. Bevan
- 2.3.11 Acromegaly John A. H. Wass, Peter J. Trainer, Márta Korbonits
- 2.3.12 Clinically nonfunctioning pituitary tumours and gonadotropinomas W. W. de Herder, R. A. Feelders, A. J. van der Lely
- 2.3.13 Thyrotropinomas Paolo Beck-Peccoz, Luca Persani
- 2.3.14 Pituitary carcinoma John Ayuk, Christopher J. McCabe, Neil J. L. Gittoes
- 2.3.15 Pituitary incidentalomas Niki Karavitaki
- 2.4 Aetiology, pathogenesis, and management of diseases of the hypothalamus
- 2.4.1 Hypothalamic dysfunction (hypothalamic syndromes) M. Guftar Shaikh
- 2.4.2 Craniopharyngiomas Niki Karavitaki
- 2.4.3 Perisellar tumours including cysts, hamartomas, and vascular tumours Jürgen Honegger, Rudi Beschorner, Ulrike Ernemann
- 2.4.4 Lymphocytic hypophysitis and other inflammatory conditions of the pituitary Jelena Kravarusic, Mark E. Molitch
- 2.5 Pineal physiology and pathophysiology, including pineal tumours Anna Aulinas, Cristina Colom, Susan M. Webb
- 2.6 Neuropsychiatric endocrinological disorders
- 2.6.1 Endocrinology, sleep and circadian rhythms G. Brabant
- 2.6.2 Endocrinology of eating disorders Gerasimos E. Krassas, Luigi Bartalena
- 2.6.3 The endocrine response to stress David E. Henley, Joey M. Kaye, Stafford L. Lightman
- 2.6.4 Endocrinology and alcohol Margit G. Proescholdt, Marc Walter
- Part 3 The thyroid
- 3.1 Evaluation of the thyroid patient
- 3.1.1 The history and iconography relating to the thyroid gland Robert Volpé and Clark Sawin
- 3.1.2 Biosynthesis, transport, metabolism, and actions of thyroid hormones Theo J. Visser
- 3.1.3 Clinical assessment of the thyroid patient Peter Laurberg, Inge Bülow Pedersen
- 3.1.4 Thyroid function tests and the effects of drugs Jim Stockigt
- 3.1.5 Nonthyroidal illness R.P. Peeters
- 3.1.6 Thyroid imaging: nuclear medicine techniques I. Ross McDougall, Andrei Iagaru
- 3.1.6.1 Thyroid imaging: nonisotopic techniques Laszlo Hegedüs, Finn N. Bennedbæk
- 3.1.7 Epidemiology of thyroid disease and swelling Mark P. J. Vanderpump
- 3.2 Aetiology of thyroid disorders
- 3.2.1 Genetic factors relating to the thyroid with emphasis on complex diseases Francesca Menconi, Terry F. Davies, Yaron Tomer
- 3.2.2 Environmental factors Josef Köhrle
- 3.2.3 Iodine deficiency disorders Michael B. Zimmermann
- 3.2.4 Disorders of iodine excess Shigenobu Nagataki, Misa Imaizumi, and Noboru Takamura
- 3.2.5 Radiation-induced thyroid disease Furio Pacini, Rossella Elisei, Aldo Pinchera
- 3.2.6 Autoimmune thyroid disease Anthony P. Weetman
- 3.2.7 Thyroiditis Beth Kaplan, Elizabeth N. Pearce, Alan P. Farwell
- 3.3 Thyrotoxicosis and related disorders
- 3.3.1 Clinical assessment and systemic manifestations of thyrotoxicosis Claudio Marcocci, Filomena Cetani, Aldo Pinchera
- 3.3.2 Thyrotoxic periodic paralysis Annie W.C. Kung
- 3.3.3 Thyrotoxic storm Joanna Klubo-Gwiezdzinska, Leonard Wartofsky
- 3.3.4 Subclinical hyperthyroidism Jayne A. Franklyn
- 3.3.5 Causes and laboratory investigations of thyrotoxicosis Francesco Latrofa, Paolo Vitti, Aldo Pinchera
- 3.3.6 Antithyroid drug treatment for thyrotoxicosis Anthony Toft
- 3.3.7 Radio-iodine treatment of hyperthyroidism Markus Luster, Michael Lassmann
- 3.3.8 Surgery for thyrotoxicosis Mauricio Moreno, Nancy D. Perrier, Orlo Clark
- 3.3.9 Management of Graves’ hyperthyroidism Jacques Orgiazzi, Claire Bournaud
- 3.3.10 Graves’ ophthalmopathy and dermopathy Wilmar M. Wiersinga
- 3.3.11 Management of toxic multinodular goitre and toxic adenoma Dagmar Führer, John H. Lazarus
- 3.3.12 Management of thyrotoxicosis without hyperthyroidism Wilmar M. Wiersinga
- 3.4 Hypothyroidism and pregnancy- and growth-related thyroid disorders
- 3.4.1 Clinical assessment and systemic manifestations of hypothyroidism Massimo Tonacchera, Luca Chiovato, Aldo Pinchera
- 3.4.2 Causes and laboratory investigation of hypothyroidism Ferruccio Santini, Aldo Pinchera
- 3.4.3 Myxoedema coma Joanna Klubo-Gwiezdzinska, Leonard Wartofsky
- 3.4.4 Subclinical hypothyroidism Jayne A. Franklyn
- 3.4.5 Thyroid disease during pregnancy John H. Lazarus, L.D. Kuvera, E. Premawardhana
- 3.4.6 Thyroid disease after pregnancy: postpartum thyroiditis Nobuyuki Amino, Sumihisa Kubota
- 3.4.7 Thyroid disease in newborns, infants, and children A.S. Paul van Trotsenburg, Thomas Vulsma
- 3.4.8 Thyroid hormone resistance syndrome Mark Gurnell and V. Krishna Chatterjee
- 3.4.9 Treatment of hypothyroidism Anthony Toft
- 3.5 Thyroid lumps
- 3.5.1 Pathogenesis of nontoxic goitre Dagmar, Führer
- 3.5.2 Management of nontoxic multinodular goitre Wilmar M. Wiersinga
- 3.5.3 Management of the single thyroid nodule Laszlo Hegedüs, Finn N. Bennedbæk
- 3.5.4 Pathogenesis of thyroid cancer Dan Mihailescu, Arthur B Schneider, Leon Fogelfeld
- 3.5.5 Pathology of thyroid cancer Yolanda C. Oertel
- 3.5.6 Papillary, follicular, and anaplastic thyroid carcinoma and lymphoma Sophie Leboulleux, Martin Jean Schlumberger
- 3.5.7 Medullary thyroid carcinoma Friedhelm Raue, Karin Frank-Raue
- 3.1 Evaluation of the thyroid patient
- Part 4 Parathyroid, calcium, and bone metabolism
- 4.1 Parathyroid anatomy, hormone synthesis, secretion, action, and receptors Geoffrey N. Hendy, David Goltzman
- 4.2 Hypercalcaemia Ronen Levi, Justin Silver
- 4.3 Primary hyperparathyroidism Shonni J. Silverberg, John P. Bilezikian
- 4.4 Familial hypocalciuric hypercalcaemia Edward M. Brown
- 4.5 Hypocalcaemic disorders, hypoparathyroidism, and pseudohypoparathyroidism Rajesh V. Thakker
- 4.6 Hypercalcaemic and hypocalcaemic syndromes in children Laleh Ardeshirpour, Thomas O. Carpenter
- 4.7 Osteoporosis Richard Eastell
- 4.8 Thyroid disorders and bone disease Moira S. Cheung, Apostolos I. Gogakos, J.H. Duncan Bassett, Graham R. Williams
- 4.9 Paget’s disease of bone Socrates E. Papapoulos
- 4.10 Rickets and osteomalacia (acquired and heritable forms) and skeletal dysplasias Michael P. Whyte, Uri A. Liberman
- 4.11 Glucocorticoid-induced osteoporosis Gherardo Mazziotti, Andrea Giustina, Ernesto Canalis, John P. Bilezikian
- Part 5 The adrenal gland and endocrine hypertension
- 5.1 Adrenal imaging Peter Guest
- 5.2 Adrenal surgery Sabapathy P. Balasubramanian, Barney J. Harrison
- 5.3 Adrenal incidentaloma Massimo Terzolo
- 5.4 Adrenocortical cancer Rossella Libè, Lionel Groussin, Xavier Bertagna, Jérôme Bertherat
- 5.5 Phaeochromocytomas, paragangliomas, and neuroblastoma Isla S. Mackenzie, Morris J. Brown
- 5.6 Primary aldosteronism and other steroid-related causes of endocrine hypertension John M.C. Connell, E. Marie Freel
- 5.7 Cushing’s syndrome John Newell-Price
- 5.8 Glucocorticoid resistance—a defect of the glucocorticoid receptor Elisabeth F. C. van Rossum, Steven W. J. Lamberts
- 5.9 Adrenal insufficiency Wiebke Arlt
- 5.10 Familial glucocorticoid deficiency Claire Hughes, Louise Metherell, Adrian J.L. Clark
- 5.11 Congenital adrenal hyperplasia Nils Krone
- Part 6 Neuroendocrine tumours and genetic disorders
- 6.1 Neuroendocrine tumours of the gastrointestinal tract: an appraisal of the past and perspectives for the future Irvin M Modlin, Bjorn I Gustafsson, Mark Kidd
- 6.2 Neuroendocrine tumour markers R. Ramachandran, W. Dhillo
- 6.3 Neuroendocrine (carcinoid) tumours and the carcinoid syndrome Rajaventhan Srirajaskanthan, Martyn E. Caplin, Humphrey Hodgson
- 6.4 Gastrinoma Christos Toumpanakis, Martyn Caplin
- 6.5 Insulinoma and hypoglycaemia Puja Mehta, Jeannie F. Todd
- 6.6 Glucagonoma G.M.K. Nijher, S.R. Bloom
- 6.7 VIPomas Katie Wynne
- 6.8 Somatostatinoma John A.H. Wass
- 6.9 Imaging neuroendocrine tumours of the gastrointestinal tract James E. Jackson, Mary E. Roddie
- 6.10 Systemic mastocytosis Tomás Ahern, Donal O’Shea
- 6.11 Multiple endocrine neoplasia type 1 R.V. Thakker
- 6.12 Multiple endocrine neoplasia type 2 Niamh M. Martin, Karim Meeran, Stephen R. Bloom
- 6.13 von Hippel–Lindau disease and succinate dehydrogenase subunit (SDHB, SDHC, and SDHD) genes Eamonn R. Maher
- 6.14 Neurofibromatosis George Tharakan
- 6.15 Carney’s complex Constantine A. Stratakis
- 6.16 Molecular and clinical characteristics of the McCune–Albright syndrome Steven A. Lietman, Michael A. Levine
- 6.17 Cowden’s syndrome Charis Eng
- Part 7 Growth and development during childhood
- 7.1 Normal growth and sexual development
- 7.1.1 Child and adolescent growth Gary Butler
- 7.1.2 Childhood endocrinology Guy Van Vliet
- 7.1.3 Sex determination and differentiation Garry L. Warne, Jacqueline K. Hewitt
- 7.1.4 Management of differences and disorders of sex development in the newborn S. Faisal Ahmed, Paula Midgley, Martina Rodie
- 7.2 Growth and sexual disorders in childhood
- 7.2.1 Hypoglycaemia: assessment and management Andrew Cotterill, David Cowley, Ristan Greer
- 7.2.2 Differential diagnosis of short stature and poor growth velocity Jesper Johannesen, Christopher T. Cowell
- 7.2.3 Genetic defects of the human somatotropic axis Louise A. Metherell, Helen L. Storr, Martin O. Savage
- 7.2.4 Investigation of the slowly growing child L. Patel, P. E. Clayton
- 7.2.5 Growth hormone therapy for the growth-hormone deficient child Jan M. Wit, Wilma Oostdijk
- 7.2.6 Growth-promoting agents for nongrowth hormone-deficient short children Pierre Chatelain
- 7.2.7 Syndromic growth disorders Thomas Edouard, Maïthé Tauber
- 7.2.8 Tall stature Primus E. Mullis
- 7.2.9 Delayed puberty and hypogonadism John S. Fuqua, Alan D. Rogol
- 7.2.10 Premature sexual maturation Jean-Claude Carel, and Juliane Léger
- 7.3 Congenital adrenal hyperplasia in children Felix G. Riepe
- 7.4 Late effects of cancer treatment Andrew A. Toogood
- 7.5 Transition in endocrinology Helena Gleeson
- 7.1 Normal growth and sexual development
- Part 8 Female endocrinology and pregnancy
- 8.1 Female endocrinology and ovarian disorders
- 8.1.1 The generation and use of human embryonic stem cells Mikael C. O. Englund, Christopher L. R. Barratt
- 8.1.2 Menstrual cycle and ovulation William L. Ledger
- 8.1.3 Hormonal contraception Bliss Kaneshiro, Alison Edelman
- 8.1.4 Premenstrual syndrome Andrea Rapkin, Mya Zapata
- 8.1.5 Primary ovarian failure Gerard S. Conway, Jacqueline Doyle, Melanie C. Davies
- 8.1.6 Disorders of gonadotropin secretion Sarah L. Berga
- 8.1.7 Hyperprolactinaemic anovulation Julian R. E. Davis
- 8.1.8 Polycystic ovary syndrome: reproductive aspects Sophie Catteau-Jonard, Cécile Gallo, Didier Dewailly
- 8.1.9 Polycystic ovary syndrome: metabolic aspects Richard S. Legro
- 8.1.10 Hirsutism Bulent O. Yildiz, Ricardo Azziz
- 8.1.11 Infertility and assisted reproduction Adam Balen
- 8.1.12 Nutrition and reproduction Siew S. Lim, Robert J. Norman
- 8.2 Pregnancy-related disorders
- 8.2.1 The endometrium: receptivity, implantation, and endometrial cancer as endocrine disease Markku Seppälä, Linda C. Giudice
- 8.2.2 Parturition Erika F. Werner, Errol R. Norwitz
- 8.2.3 Gestational trophoblastic neoplasia Philip Savage, Michael J. Seckl
- 8.2.4 The breast: lactation and breast cancer as an endocrine disease R. Santen
- 8.2.5 Endocrine disease in pregnancy C. Nelson, S. Germain
- 8.1 Female endocrinology and ovarian disorders
- Part 9 Male hypogonadism and infertilityEdited by
Eberhard Nieschlag
- 9.1 Definitions and classification of disorders Eberhard Nieschlag
- 9.2 Normal male endocrinology
- 9.2.1 The male gamete: spermatogenesis, maturation, function C. Marc Luetjens, Gerhard F. Weinbauer
- 9.2.2 Endocrine and local testicular regulation Ilpo Huhtaniemi
- 9.2.3 Testicular hormones Ilpo Huhtaniemi
- 9.3 Evaluation of the male patient with suspected hypogonadism and/or infertility
- 9.3.1 Clinical appearance and examination Eberhard Nieschlag
- 9.3.2 Endocrine evaluation Hermann M. Behre, Eberhard Nieschlag
- 9.3.3 Semen analysis Franco Dondero, Andrea Lenzi, Loredana Gandini
- 9.3.4 Sonography Hermann M. Behre, Eberhard Nieschlag
- 9.3.5 Cytogenetics and molecular genetics Dieter Meschede, Frank Tüttelmann
- 9.3.6 Testicular biopsy Wolfgang Schulze, Ulrich A. Knuth
- 9.4 Male endocrinological disorders and male factor infertility
- 9.4.1 Congenital anorchia, acquired anorchia, testicular maldescent, and varicocele H. W. Gordon Baker
- 9.4.2 Disturbed spermatogenesis Claus Rolf, Eberhard Nieschlag
- 9.4.3 Klinefelter’s syndrome Dieter Meschede, Eberhard Nieschlag
- 9.4.4 XX male Dieter Meschede, Eberhard Nieschlag
- 9.4.5 XYY male Dieter Meschede, Eberhard Nieschlag
- 9.4.6 Structural chromosome abnormalities Dieter Meschede
- 9.4.7 Sequelae of extratesticular disease David J. Handelsman
- 9.4.8 Testicular tumours Olof Ståhl, Jakob Eberhard, Aleksander Giwercman
- 9.4.9 Infections/inflammation of the genital tract Franco Dondero, Francesco Lombardo
- 9.4.10 Obstructions Franco Dondero, Francesco Lombardo
- 9.4.11 Immunological infertility Franco Dondero, Loredana Gandini, Francesco Lombardo, Andrea Lenzi
- 9.4.12 Idiopathic infertility Eberhard Nieschlag
- 9.4.13 Treatment of hypogonadism and infertility Eberhard Nieschlag
- 9.4.14 Insemination, in vitro fertilization, and intracytoplasmic sperm injection Herman J. Tournaye
- 9.4.15 Cryopreservation of sperm A. Kamischke, Eberhard Nieschlag
- 9.4.16 Sexuality and erectile dysfunction Cesare Carani, Vincenzo Rochira, Antonio R. M. Granata
- 9.4.17 Gynaecomastia Louis J. G. Gooren
- 9.4.18 Transsexualism Louis J. G. Gooren
- 9.5 Exogenous factors and male reproductive health
- 9.5.1 Environmental influences on male reproductive health Aleksander Giwercman
- 9.5.2 Androgen misuse and abuse David J. Handelsman
- 9.5.3 Male reproductive health Louis J. G. Gooren
- Part 10 Endocrinology of ageing and systemic disease
- 10.1 Ageing and the endocrine system
- 10.1.1 Growth hormone and ageing James Gibney, Ken K. Y. HO
- 10.1.2 Endocrinology of the menopause and hormone replacement therapy Henry G. Burger, Helena J. Teede
- 10.1.3 Male reproductive health and ageing David J. Handelsman
- 10.1.4 Dehydroepiandrosterone and ageing Wiebke Arlt
- 10.1.5 Ageing and thyroid disease Stefano Mariotti
- 10.1.6 Bone disease in older people R. L. Prince
- 10.2 Endocrinology of systemic disease
- 10.2.1 Hormones and the kidney Jong Chan Park, Raimund Hirschberg
- 10.2.2 The endocrinology of liver disease Alessandro Antonelli, Clodoveo Ferri, Poupak Fallahi
- 10.2.3 Endocrinology in the critically ill Hilke Vervenne, Greet Van den Berghe
- 10.2.4 Endocrine abnormalities in HIV infection Takara L. Stanley, Steven K. Grinspoon
- 10.2.5 Immunoendocrinopathy syndromes W. A. Scherbaum, M. Schott
- 10.1 Ageing and the endocrine system
- Part 11 Endocrinology of cancer
- 11.1 Secondary endocrine tumours, ectopic hormone syndromes, and effects of cancer treatment on endocrine function
- 11.1.1 Metastatic disease in endocrine organs Michael Monteiro, David Lowe
- 11.1.2 Ectopic hormone syndromes David W. Ray
- 11.1.3 Long-term endocrine sequelae of cancer therapy Robert D. Murray
- 11.2 Hormonal therapy for breast and prostatic cancers
- 11.2.1 Endocrine treatment of breast cancer Amna Sheri, Stephen Johnston
- 11.2.2 Hormonal therapy of prostate cancer Ciara O’Hanlon Brown, Jonathan Waxman
- 11.1 Secondary endocrine tumours, ectopic hormone syndromes, and effects of cancer treatment on endocrine function
- Part 12 Obesity, lipids, and metabolic disorders
- 12.1 Epidemiology, aetiology, and management of obesity
- 12.1.1 Obesity as a health problem Stefan Rossner
- 12.1.2 Genetics of obesity Karine Clément
- 12.1.3 Assessment and management of severe obesity in childhood and adolescence Ram Weiss
- 12.1.4 Assessment and management of severe obesity in adults I. Sadaf Farooqi
- 12.1.5 Weight regulation: physiology and pathophysiology Saira Hameed, Waljit S. Dhillo
- 12.2 Lipoprotein metabolism and related diseases
- 12.2.1 Lipoprotein metabolism Bo Angelin, Paolo Parini
- 12.2.2 Familial hypercholesterolaemia Gilbert R. Thompson
- 12.2.3 Genetic defects in sterol synthesis, absorption, and degradation into bile acids Stefano Romeo
- 12.3 Other metabolic disorders
- 12.3.1 Disorders of carbohydrate metabolism Robin H. Lachmann
- 12.3.2 Haemochromatosis K.J. Allen
- 12.3.3 The porphyrias Michael N. Badminton, George H. Elder
- 12.1 Epidemiology, aetiology, and management of obesity
- Part 13 Diabetes mellitus
- 13.1 Classification and diagnosis of diabetes mellitus K. George M.M. Alberti, Paul Zimmet
- 13.2 Aetiology and pathogenesis of type 1 diabetes mellitus
- 13.2.1 Clinical features of type 1 diabetes mellitus Stephanie A. Amiel
- 13.2.2 Genetics of type 1 diabetes mellitus David A. Savage, Stephen C. Bain
- 13.2.3 Immunology of type 1 diabetes mellitus Mark Peakman
- 13.3 Aetiology and pathogenesis of type 2 diabetes mellitus
- 13.3.1 Genetics of type 2 diabetes mellitus Niels Grarup, Torben Hansen, Oluf Pedersen
- 13.3.2 Pathophysiology of type 2 diabetes mellitus Hannele Yki-Järvinen
- 13.3.3 Epidemiology of type 2 diabetes mellitus Sarah Wild, Jackie Price
- 13.3.4 Monogenic forms of diabetes resulting from β cell dysfunction Rachel Besser, Andrew Hattersley
- 13.3.5 Genetics of severe insulin resistance Robert K. Semple, David B. Savage, Stephen O'Rahilly
- 13.3.6 Metabolic syndrome Harold E. Lebovitz
- 13.4 Management of diabetes mellitus
- 13.4.1 Clinical features, lifestyle management, and glycaemic targets in type 2 diabetes mellitus David Matthews, Usha Ayyagari, Pamela Dyson
- 13.4.2 Pharmacological therapy of hyperglycaemia in type 2 diabetes mellitus Clifford J. Bailey, Melanie J. Davies
- 13.4.3 Diabetes in diverse ethnic groups
- 13.4.3.1 The world pandemic of diabetes Nigel Unwin
- 13.4.3.2 Diabetes in South Asians A. Ramachandran, C. Snehalatha
- 13.4.3.3 Diabetes in the South Asian diaspora Srikanth Bellary, Kamlesh Khunti, Anthony H. Barnett
- 13.4.3.4 Diabetes in sub-Saharan Africa and in Africans Eugène Sobngwi
- 13.4.4 Structured education for people with type 2 diabetes mellitus Simon R. Heller, Marian E. Carey
- 13.4.5 Metabolic surgery in the treatment of type 2 diabetes mellitus David E. Cummings
- 13.4.6 Management of type 1 diabetes mellitus Simon R. Heller
- 13.4.7 Type 1 and type 2 diabetes mellitus in children Krystyna A. Matyka
- 13.4.8 Hypoglycaemia in the treatment of diabetes mellitus Pratik Choudhary, Stephanie A. Amiel
- 13.4.9 Non-biological technologies in glucose sensing
- 13.4.9.1 Glucose monitoring John C. Pickup
- 13.4.9.2 Closing the loop Roman Hovorka
- 13.4.10 Management of diabetes mellitus in special situations
- 13.4.10.1 Hyperglycaemic crises in adult patients with diabetes mellitus Abbas E. Kitabchi, Ebenezer Nyenwe
- 13.4.10.2 Diabetic ketoacidosis in childhood and adolescence M. Silink
- 13.4.10.3 Management of the inpatient with diabetes mellitus Paul G. McNally, Maggie Sinclair Hammersley
- 13.4.10.4 Insulin therapy in the intensive care unit Greet Van den Berghe, Yoo-Mee Vanwijngaerden, Dieter Mesotten
- 13.4.10.5 Diabetes management in surgery Andrew P. Hall, Melanie J. Davies
- 13.4.10.6 Diabetes management in pregnancy David R. McCance
- 13.5 Microvascular complications
- 13.5.1 Pathogenesis of microvascular disease Angela C. Shore
- 13.5.2 Diabetic retinopathy Catherine M. Guly, Jane R. MacKinnon, John V. Forrester
- 13.5.3 Diabetic nephropathy Janaka Karalliedde, Giancarlo Janaka
- 13.5.4 Diabetic neuropathy Solomon Tesfaye
- 13.6 Macrovascular diseases and diabetes mellitus
- 13.6.1 Mechanisms of macrovascular disease in diabetes Peter J. Grant, Mark T. Kearney
- 13.6.2 Prediction models for cardiovascular disease in diabetes mellitus Amanda I. Adler, Simon Griffin
- 13.6.3 Diabetic dyslipidaemia John Betteridge
- 13.6.4 Hypertension in diabetes mellitus Bryan Williams
- 13.7 The diabetic foot Michael Edmonds, Alethea. Foster
- 13.8 Mental health and diabetes mellitus
- 13.8.1 Depression and diabetes mellitus Khalida Ismail, Frank Petrak
- 13.8.2 Diabetes mellitus and psychotic disease John W. Newcomer
- 13.9 Organization of diabetes care
- 13.9.1 Organizing a diabetes service Stephen C. L. Gough
- 13.9.2 The informatics of diabetes management John P. New, Iain E. Buchan
- 13.10 Transplantation in Diabetes
- 13.10.1 Treatment of diabetes (Type I) through transplantation Parthi Srinivasan
- 13.10.2 Diabetes mellitus and transplantation Paul Riley, John O’Grady
- 13.11 Gene therapy in diabetes mellitus James A. M. Shaw, Kevin Docherty
- End Matter
