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Anaesthetic pharmacology and obesity 

Anaesthetic pharmacology and obesity
Anaesthetic pharmacology and obesity

Mark Bellamy

and Michel Struys

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date: 26 November 2020

Many drugs behave differently in obese and non-obese subjects.

This results from both pharmacokinetic and pharmacodynamic factors.

mg/kg doses provided by manufacturers are based on total body weight in the lean patient population and have limited relevance to total body weight in the obese.

Drug dose may be based on total body weight, ideal body weight, or lean body mass depending on the drug.

There is great variability between individual subjects.

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