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Physiology of obesity, molecular, and medical approaches 

Physiology of obesity, molecular, and medical approaches
Physiology of obesity, molecular, and medical approaches

Mark Bellamy

and Michel Struys

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date: 28 November 2020

Many overweight and obese people have an extremely negative body image.

Poor body image may contribute to the persistence of obesity.

Reduction in activity and increased calorie consumption are obligatory consequences of obesity, not simply causes of obesity.

The pathways of energy balance represent a three limb process, orchestrated by the hypothalamus.

There is probably a strong individual genetic component, with everyone having their own ‘leptin set point’.

Medical strategies include behaviour and lifestyle modification, and drug therapy.

The contribution of pharmacological therapy is limited.

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