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Infection and inflammation 

Infection and inflammation
Infection and inflammation

Carl Waldmann

, Neil Soni

, and Andrew Rhodes

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date: 09 May 2021

Pathophysiology of sepsis and multi-organ failure 462

Infection control—general principles 464

HIV 466

Severe falciparum malaria 468

Vasculitides in the ICU 470

Source control 472

Selective decontamination of the digestive tract (SDD) 474

Markers of infection 476

Adrenal insufficiency and sepsis 478

Infectious agents entering the body lead to local inflammation, pus and abscess formation, and affect the whole body through systemic inflammation. Systemic inflammation is recognized by the presence of fever, abnormal WCC, and increased heart and respiratory rate, and is known as systemic inflammatory response syndrome (SIRS). If SIRS is due to infection (as distinct from other causes such as pancreatitis, burns or major trauma) it is defined as sepsis....

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