Show Summary Details
Page of

Renal disorders 

Renal disorders
Chapter:
Renal disorders
Author(s):

Carl Waldmann

, Neil Soni

, and Andrew Rhodes

DOI:
10.1093/med/9780199229581.003.0019
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2021. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 09 May 2021

Prevention of acute renal failure 312

Diagnosis of acute renal failure 314

Acute kidney injury (AKI) often complicates the course of critical illness and was previously considered as a marker rather than a cause of adverse outcomes, it is independently associated with an increase in both morbidity and mortality. The major causes of AKI in the ICU include hypoperfusion, sepsis and direct nephrotoxicity, with the common aetiology believed to be a change in intrarenal haemodynamics with resultant acute tubular dysfunction and oxidant stress. Treatment of established acute renal failure in the ICU entails the use of RRT by means of various modalities, although this therapy itself carries an inherent morbidity and risk. Therefore, preventing or minimizing renal injury should confer a benefit to patients. Consequently, several pharmacological interventions have been tried to treat AKI. These interventions can be separated into measures influencing renal perfusion and measures modulating intrarenal pathophysiology....

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.