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Haematological drugs 

Haematological drugs
Chapter:
Haematological drugs
Author(s):

Carl Waldmann

, Neil Soni

, and Andrew Rhodes

DOI:
10.1093/med/9780199229581.003.0014
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date: 09 May 2021

Anticoagulants and heparin-induced thrombocytopenia 220

Thrombolysis 224

Antifibrinolytics 226

For >50 years, the options for therapeutic anticoagulation were limited to unfractionated heparin (UFH) and oral vitamin K antagonists. While highly effective, both drugs have major safety problems. Both have narrow therapeutic ranges, substantial interindividual dose variability, major side effects and require regular therapeutic drug monitoring, with a narrow therapeutic window and high incidence of bleeding complications....

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