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Gastrointestinal drugs 

Gastrointestinal drugs
Chapter:
Gastrointestinal drugs
Author(s):

Carl Waldmann

, Neil Soni

, and Andrew Rhodes

DOI:
10.1093/med/9780199229581.003.0012
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date: 05 May 2021

H2 blockers and proton pump inhibitors 194

Antiemetics 196

Gut motility agents 198

Antidiarrhoeals 200

Constipation in critical care 202

There is continual basal acid secretion and an increase after meals, from the parietal cells in the body and fundus of the stomach. The dominant mechanism for acid secretion is mediated by histamine from enterochromaffin cells, in turn stimulated by gastrin, released from antral G cells in response to amino acids. Other stimuli acting on parietal cells include acetylcholine, gastrin, calcium and pituitary adenylate cyclase-activating polypeptide....

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