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Pharmacology and drug use in kidney disease 

Pharmacology and drug use in kidney disease
Chapter:
Pharmacology and drug use in kidney disease
Author(s):

Jonathan Barratt

, Kevin Harris

, and Peter Topham

DOI:
10.1093/med/9780199229567.003.0018
Page of

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date: 24 January 2021

Handling of drugs in kidney disease 690

Drug-induced nephropathies 698

Clinical use of diuretics 708

Systemic cancer therapies and the kidney 714

The handling of drugs in the body (pharmacokinetics) is significantly altered in renal disease and also by the reduction in renal function with advancing age. Many drugs, and some active metabolites, are eliminated by the kidney, either by glomerular filtration or tubular secretion. Patients with kidney disease, and especially those who require dialysis, are often on multiple drugs....

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