- Contributors
- Preface
- Part I Pain in patients with cancer
- Chapter 1 The principles of management of pain due to cancer
- Part II Treatment of cancer pain
- Chapter 2 The range of treatments for pain due to cancer
- Chapter 3 The development and efficacy of the WHO analgesic ladder
- Part III Opioids in cancer pain
- Chapter 4 Opioid receptors
- Chapter 5 Starting opioids for moderate to severe pain: talking to the patient
- Chapter 6 Principles of opioid titration
- Chapter 7 Management of adverse effects
- Part IV Oral opioids
- Chapter 8 Morphine
- Chapter 9 Oxycodone
- Chapter 10 Hydromorphone
- Chapter 11 Methadone
- Chapter 12 Other alternative oral opioids
- Part V Alternative routes of administration
- Chapter 13 Transdermal opioids
- Chapter 14 Other routes of opioid administration
- Chapter 15 Spinal opioids
- Chapter 16 Parenteral opioids
- Chapter 17 Opioids in special circumstances
- Appendix Dose conversion when switching from oral morphine to transdermal fentanyl
- Index
(p. 27) Opioid receptors
- Chapter:
- (p. 27) Opioid receptors
- Author(s):
Catherine E. Urch
- DOI:
- 10.1093/med/9780199218806.003.0004
There are four members of the opioid receptor family mu, delta, kappa and ORL-1. G protein linked receptors. Acute response to ligand binding differs from chronic response. Acute response includes dimerisation, endocytosis and inhibition of adenylyl cyclase, cAMP systems and hyperpolarization of the neuron. Chronic response includes altered G protein, adenylyl cyclase proteins, increased phosphorylation, receptor modulation, rectification of hyperpolarization and attenuation of extreme inhibition. New altered receptor activation and cell inhibition state achieved. Polymorphisms in receptor and enzyme pathways give insight into inter-individual response.
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- Contributors
- Preface
- Part I Pain in patients with cancer
- Chapter 1 The principles of management of pain due to cancer
- Part II Treatment of cancer pain
- Chapter 2 The range of treatments for pain due to cancer
- Chapter 3 The development and efficacy of the WHO analgesic ladder
- Part III Opioids in cancer pain
- Chapter 4 Opioid receptors
- Chapter 5 Starting opioids for moderate to severe pain: talking to the patient
- Chapter 6 Principles of opioid titration
- Chapter 7 Management of adverse effects
- Part IV Oral opioids
- Chapter 8 Morphine
- Chapter 9 Oxycodone
- Chapter 10 Hydromorphone
- Chapter 11 Methadone
- Chapter 12 Other alternative oral opioids
- Part V Alternative routes of administration
- Chapter 13 Transdermal opioids
- Chapter 14 Other routes of opioid administration
- Chapter 15 Spinal opioids
- Chapter 16 Parenteral opioids
- Chapter 17 Opioids in special circumstances
- Appendix Dose conversion when switching from oral morphine to transdermal fentanyl
- Index